Hamilton Morris and Dr. Mark Plotkin — Exploring the History of Psychoactive Substances, Synthetic vs. Natural Options, Microdosing, 5-MeO-DMT, The “Drunken Monkey” Hypothesis, Timothy Leary’s Legacy, and More | Brought to you by Athletic Greens all-in-one nutritional supplement and 5-Bullet Friday, my very own email newsletter. More on both below.Welcome to The Tim Ferriss Show, where it is usually my job to deconstruct world-class performers, to tease out their routines, habits, et cetera that you can apply to your own life. This time around, we have a very special edition featuring two of your favorite guests: Dr. Mark Plotkin and Hamilton Morris. Mark takes over my duties as host and interviews Hamilton for an episode of the Plants of the Gods podcast. You, my dear listeners, are hearing the audio before anyone else, so this is a Tim Ferriss Show exclusive. I’ve previously featured some of my favorite episodes from that show at tim.blog/plantsofthegods. These episodes cover a lot of fascinating ground.Who is Mark? Mark (@DocMarkPlotkin) is an ethnobotanist who serves as president of the Amazon Conservation Team, which has partnered with ~80 tribes to map and improve management and protection of ~100 million acres of ancestral rainforests. He is best known to the general public as the author of the book Tales of a Shaman’s Apprentice, one of the most popular books ever written about the rainforest. His most recent book is The Amazon: What Everyone Needs to Know. You can find my interview with Mark at tim.blog/markplotkin. And the guest today is Hamilton Morris. Hamilton (@HamiltonMorris) is a chemist, filmmaker, and science journalist. A graduate of The New School, he conducts chemistry research at Saint Joseph’s University. Hamilton is the writer and director of the documentary series Hamilton’s Pharmacopeia, in which he explores the chemistry and traditions surrounding psychoactive drugs. You can find my most recent interview with him at tim.blog/hamilton.  This is a tightly packed 60-minute interview. Mark and Hamilton cover the history of different psychoactive substances, Timothy Leary’s legacy, the “drunken monkey” hypothesis, conservation, microdosing, the differences between 5-MeO-DMT and DMT, a disease that afflicts people who smoke enormous quantities of cannabis, causing them to vomit continuously and only find relief from their nausea by taking a hot shower (yes, really), the impact of the placebo effect, a synthetic vs. a natural product, the role of ritual, and much, much more. Please enjoy!*This episode is brought to you by Athletic Greens. I get asked all the time, “If you could use only one supplement, what would it be?” My answer is usually AG1 by Athletic Greens, my all-in-one nutritional insurance. I recommended it in The 4-Hour Body in 2010 and did not get paid to do so. I do my best with nutrient-dense meals, of course, but AG further covers my bases with vitamins, minerals, and whole-food-sourced micronutrients that support gut health and the immune system. Right now, Athletic Greens is offering you their Vitamin D Liquid Formula free with your first subscription purchase—a vital nutrient for a strong immune system and strong bones. Visit AthleticGreens.com/Tim to claim this special offer today and receive the free Vitamin D Liquid Formula (and five free travel packs) with your first subscription purchase! That’s up to a one-year supply of Vitamin D as added value when you try their delicious and comprehensive all-in-one daily greens product.*This episode is also brought to you by 5-Bullet Friday, my very own email newsletter that every Friday features five bullet points highlighting cool things I’ve found that week, including apps, books, documentaries, gadgets, albums, articles, TV shows, new hacks or tricks, and—of course—all sorts of weird stuff I’ve dug up from around the world.It’s free, it’s always going to be free, and you can subscribe now at tim.blog/friday.*[06:22] The Sonoran desert toad's celebrity star is rising[08:18] The role of the chemist in preserving plants, animals, and fungi from which compounds are traditionally derived[11:18] Who is Howard Lotsof?[14:02] Microdosing[16:39] Ken Nelson and the celebrated Bufo Alvarius: The Psychedelic Toad of the Sonoran Desert pamphlet[20:11] God molecule vs. just plain old DMT[22:25] There are potential downsides to these compounds (even cannabis)[27:58] Undiscovered compounds[30:15] Lessons learned and questions pondered from Alexander Shulgin's thumb surgery[34:05] Synthetic vs. natural[37:21] The role of ritual[39:49] Combining traditions[42:27] Mark's account of Huautla in the early 2000s.[42:58] Downsides of psychedelic tourism[47:46] Effectiveness of fungi vs. frogs[49:52] Where do we go in search of new substances?[53:11] How far back do shamanic traditions go?[54:40] Poisons as medicines and vice versa[56:34] Salvia, and stoned vs. drunk apes[1:04:20] Nicolas Langlitz and the primatology of primatologists[1:06:03] Timothy Leary's legacy*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Hamilton Morris on Iboga, 5-MeO-DMT, The Power of Ritual, New Frontiers in Psychedelics, Excellent Problems to Solve, and More | Brought to you by Dry Farm Wines natural wines designed for fewer hangovers, LMNT electrolyte supplement, and Oura smart ring wearable for personalized sleep and health insights. More on all three below.Hamilton Morris (@HamiltonMorris) is a chemist, filmmaker, and science journalist. A graduate of The New School, he conducts chemistry research at The University of the Sciences in Philadelphia.Hamilton is the writer and director of the documentary series Hamilton’s Pharmacopeia, in which he explores the chemistry and traditions surrounding psychoactive drugs. His research has allowed him to study psychoactive plants, fungi, and chemicals, as well as the culture that surrounds them, in more than 30 countries, using an interdisciplinary approach that combines anthropology and chemistry.Hamilton’s recent republishing of a book on Bufo alvarius has, at the time of writing, raised more than $205,000 for Parkinson’s disease research.Please enjoy!This episode is brought to you by Dry Farm Wines. I’m a wine drinker, and I love a few glasses over meals with friends. That said, I hate hangovers. For the last few months, most of the wine in my house has been from Dry Farm Wines. Why? At least in my experience, their wine means more fun with fewer headaches. Dry Farm Wines only ships wines that meet very stringent criteria: practically sugar free (less than 0.15g per glass), lower alcohol (less than 12.5% alcohol), additive free (there are more than 70 FDA-approved wine-making additives), lower sulfites, organic, and produced by small family farms.All Dry Farm Wines are laboratory tested for purity standards by a certified, independent enologist, and all of their wines are also backed by a 100% Happiness Promise—they will either replace or refund any wine you do not love. Last but not least, I find delicious wines I never would have found otherwise. It’s a lot of fun. Dry Farm Wines has a special offer just for listeners of the podcast—an extra bottle in your first box for just one extra penny. Check out all the details at DryFarmWines.com/Tim.*This episode is also brought to you by Oura! Oura is the company behind the smart ring that delivers personalized sleep and health insights to help you optimize just about everything. I’ve been using it religiously for at least six months, and I was introduced to it by Dr. Peter Attia. It is the only wearable that I wear on a daily basis.With advanced sensors, Oura packs state-of-the-art heart rate, heart-rate variability, temperature, activity, and sleep monitoring technology into a convenient, non-invasive ring. It weighs less than 6 grams and focuses on three key insights—sleep, readiness, and activity.Try it for yourself. The Oura Ring comes in two styles and three colors: Silver, Black, and Matte Black. For $299, you can give or get the gift of health by visiting OuraRing.com.*This episode is also brought to you by LMNT! What is LMNT? It’s a delicious, sugar-free electrolyte drink-mix. I’ve stocked up on boxes and boxes of this and usually use it 1–2 times per day. LMNT is formulated to help anyone with their electrolyte needs and perfectly suited to folks following a keto, low-carb, or Paleo diet. If you are on a low-carb diet or fasting, electrolytes play a key role in relieving hunger, cramps, headaches, tiredness, and dizziness.LMNT came up with a very special offer for you, my dear listeners. They’ve created Tim’s Club: Simply go to DrinkLMNT.com/Tim and select “Subscribe & Save” on any 30-count box of LMNT for only $36. This will be valid for the lifetime of the subscription and you can pause it anytime. And perfect for the warm days, they have a new flavor, Watermelon Salt, which I've been quite enjoying.*If you enjoy the podcast, would you please consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it really makes a difference in helping to convince hard-to-get guests. I also love reading the reviews!For show notes and past guests, please visit tim.blog/podcast.Sign up for Tim’s email newsletter (“5-Bullet Friday”) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissFacebook: facebook.com/timferriss YouTube: youtube.com/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, and many more. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A LIVE DTFH recorded at the Bell House in Brooklyn with Hamilton Morris (Hamilton's Pharmacopia, VICE) and Emil Amos (Holy Sons, OM).

Hamilton Morris, a psychedelic journalist and researcher, explores the history and effects of lesser-known compounds like bufotenin. He shares insights from his work on Hamilton's Pharmacopeia and discusses the limitations of reductionist approaches to understanding psychedelics. The podcast also touches on the importance of a balanced perspective in psychedelic journalism and references influential figures such as Alexander Shulgin and Terrence McKenna.

Podcast host Hamilton Morris answers questions on various topics including pharmahuasca methodology, hydrolysis of 4-hydroxytryptamines, LSD licenses, Dr. John Mack's work on alien abduction, psychedelics as cognitive enhancers, shared hallucinations, and chemistry ASMR.