Claire Harrison, MD, a renowned expert from Guy’s and St Thomas’ NHS Foundation Trust, shares insights on cutting-edge developments in myelofibrosis therapies post-ASH. She discusses the promising RESTORE trial for l-ritrecept and highlights innovative combinations like regulatory T-cells with ruxolitinib. Exciting updates on the SANRECO trial for polycythemia vera show a reduction in phlebotomy needs, while new agents such as Nuvisertib promise significant patient outcomes. The potential of groundbreaking treatments is transforming the landscape of myelofibrosis management.

Experts Mary Frances McMullin and Claire Harrison discuss strategies to manage anemia in myelofibrosis, explore emerging trials in the UK for MPN patients, and touch upon approaches for young patients with MPNs. Topics include combination treatments, ongoing trials, LSD1 inhibitors, and the use of Nivita Mandolin for suboptimal responders.