Managing anemia in MF, key emerging trials in the UK, and approaching young patients with MPNs
May 3, 2024
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Experts Mary Frances McMullin and Claire Harrison discuss strategies to manage anemia in myelofibrosis, explore emerging trials in the UK for MPN patients, and touch upon approaches for young patients with MPNs. Topics include combination treatments, ongoing trials, LSD1 inhibitors, and the use of Nivita Mandolin for suboptimal responders.
Anemia in MF requires investigation into underlying causes like hematonic deficiency, autoimmune disease, before treatment.
Promising MPN trials in the UK focus on LSD1 inhibitors, calreticulin-directed therapies, and hepcidin agonists for PV.
Deep dives
Management of Anemia in Myeloproliferative Neoplasms
In the podcast, Mary Francis McMullen emphasizes the challenges of managing anemia in myeloproliferative neoplasms. She discusses the importance of investigating potential causes of anemia, such as hematonic deficiency or autoimmune disease, before initiating treatment. McMullen suggests using erythropoietin-stimulating agents and other medications like danazol to address anemia. Additionally, she highlights newer agents like Momelotinib as potential first-line choices for treating anemia in patients with myelofibrosis.
Promising Trials and Therapies for Myeloproliferative Disorders
Claire Harrison provides insights into the promising clinical trials and therapies for myeloproliferative disorders. She mentions studies focusing on LSD1 inhibitors and calreticulin-directed therapies for essential thrombocythemia patients. Harrison also discusses the use of hepcidin agonists in polycythemia vera and the benefits of Ruxolitinib in reducing event-free survival. Furthermore, she highlights ongoing trials involving combinations of medications to improve treatment outcomes for patients.
Focus on Young Patients with Myeloproliferative Neoplasms
The podcast addresses the unique challenges faced by young patients with myeloproliferative neoplasms. The discussion revolves around the lack of evidence-based guidelines for managing young patients and the need to tailor treatment approaches for this specific population. Efforts are being made to gather data on outcomes and treatment responses in young individuals diagnosed with these disorders. Collaborative initiatives aim to create guidelines and provide support for young patients to address their unmet needs effectively.
Myelofibrosis (MF) is a hematologic malignancy that causes progressive bone marrow fibrosis and presents with other clinical manifestations, including anemia and splenomegaly. MF-related anemia can be challenging to manage, and strategies are being explored to improve outcomes for patients.
Today’s VJHemOnc podcast features experts Mary Frances McMullin, MD, Queen’s University, Belfast, UK, who discusses strategies to manage anemia in MF, and Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, who gives a comprehensive overview of promising MPN clinical trials in the UK, and further discusses how to approach young patients with MPNs.