VJHemOnc Podcast
Managing anemia in MF, key emerging trials in the UK, and approaching young patients with MPNs
May 3, 2024
Experts Mary Frances McMullin and Claire Harrison discuss strategies to manage anemia in myelofibrosis, explore emerging trials in the UK for MPN patients, and touch upon approaches for young patients with MPNs. Topics include combination treatments, ongoing trials, LSD1 inhibitors, and the use of Nivita Mandolin for suboptimal responders.
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Quick takeaways
- Anemia in MF requires investigation into underlying causes like hematonic deficiency, autoimmune disease, before treatment.
- Promising MPN trials in the UK focus on LSD1 inhibitors, calreticulin-directed therapies, and hepcidin agonists for PV.
Deep dives
Management of Anemia in Myeloproliferative Neoplasms
In the podcast, Mary Francis McMullen emphasizes the challenges of managing anemia in myeloproliferative neoplasms. She discusses the importance of investigating potential causes of anemia, such as hematonic deficiency or autoimmune disease, before initiating treatment. McMullen suggests using erythropoietin-stimulating agents and other medications like danazol to address anemia. Additionally, she highlights newer agents like Momelotinib as potential first-line choices for treating anemia in patients with myelofibrosis.
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