VJHemOnc Podcast cover image

VJHemOnc Podcast

Post-ASH MPN highlights: key trial updates in MF, novel approaches being explored in R/R disease, & more!

Jan 28, 2025
Claire Harrison, MD, a renowned expert from Guy’s and St Thomas’ NHS Foundation Trust, shares insights on cutting-edge developments in myelofibrosis therapies post-ASH. She discusses the promising RESTORE trial for l-ritrecept and highlights innovative combinations like regulatory T-cells with ruxolitinib. Exciting updates on the SANRECO trial for polycythemia vera show a reduction in phlebotomy needs, while new agents such as Nuvisertib promise significant patient outcomes. The potential of groundbreaking treatments is transforming the landscape of myelofibrosis management.
22:21

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Recent trials indicate that combining amethylstat and roxalitinib may enhance survival for myelofibrosis patients with suboptimal responses.
  • The Sanreco trial shows promising results for polycythemia vera, significantly reducing phlebotomy needs through targeted hepcidin production therapies.

Deep dives

Advancements in Myelofibrosis Treatment

Recent research highlights significant advancements in myelofibrosis treatments, particularly with the IMPROVE-MF trial, which investigates the combination of amethylstat and roxalitinib for patients with suboptimal responses to roxalitinib alone. Findings suggest that higher doses of imetelstat may lead to improved patient survival, indicating potential disease-modifying properties particularly targeting malignant hematopoietic stem cells. Similarly, a novel approach involves utilizing regulatory T-cells alongside ruxolitinib to address persistent inflammatory pathways impacting treatment effectiveness. Preliminary results have shown positive safety profiles and symptom improvement across various phases of these trials, propelling the momentum for further investigation.

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