Carl June, MD, a pioneer in immunotherapy and director of the Center for Cellular Immunotherapy at UPenn, shares his groundbreaking journey in gene therapy. He details his transition from engineering to medicine and recounts the pivotal moments that led to FDA approval for CAR T-cell therapy. Dr. June shares inspiring patient stories, discusses future innovations in cell therapies, and addresses the challenges of work-life balance in with scientific careers. He even reveals his passion for extreme biking as a metaphor for perseverance in both life and science.