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ASGCT Podcast Network
03 - Carl June, MD - Giants of Gene Therapy
Jan 17, 2023
Carl June, MD, a pioneer in immunotherapy and director of the Center for Cellular Immunotherapy at UPenn, shares his groundbreaking journey in gene therapy. He details his transition from engineering to medicine and recounts the pivotal moments that led to FDA approval for CAR T-cell therapy. Dr. June shares inspiring patient stories, discusses future innovations in cell therapies, and addresses the challenges of work-life balance in with scientific careers. He even reveals his passion for extreme biking as a metaphor for perseverance in both life and science.
46:22
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Quick takeaways
- Dr. Carl June's pioneering work in CAR T-cell therapy, leading to its FDA approval in 2017, has revolutionized cancer treatment for refractory blood cancers.
- The future of cell and gene therapy is promising, with advancements like CRISPR enabling more personalized therapies and overcoming challenges in treating solid tumors.
Deep dives
Dr. Karl June's Background and Early Career
Dr. Karl June grew up in the San Francisco Bay Area, where his father's background as a chemical engineer sparked an early interest in science. Initially accepted to Stanford, he instead attended the Naval Academy due to his low draft number during the Vietnam War. Following his undergraduate studies, he was granted a scholarship to attend Baylor College of Medicine, where he developed a passion for immunology, driven in part by his family's history with autoimmune diseases. His early experiences in the Navy and training at esteemed institutions laid the groundwork for his future pioneering work in cellular immunotherapy.
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