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03 - Carl June, MD - Giants of Gene Therapy

ASGCT Podcast Network

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Innovations in CAR T-Cell Therapy

This chapter explores the evolution of CAR T-cell therapy, particularly its innovative use of HIV vectors and the significant breakthroughs in treating chronic lymphocytic leukemia. It recounts personal patient stories, including the dramatic recovery of Emily Whitehead during a critical cytokine storm, and discusses the transformative impact of FDA approval. The conversation also highlights future directions in cell therapy, including CAR-NK and CAR-macrophage technologies, while addressing challenges in access, manufacturing, and ethics.

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