From Bench to Fireside

From CAR T-Cell Therapy to the Impact of Mentorship with Carl June, MD

Jan 27, 2025
Join Carl June, MD, the Father of CAR T-cell therapy, as he discusses the groundbreaking approval of CAR T-cell therapy and its implications for cancer treatment. He dives into the evolution of cancer immunotherapy and the revolutionary potential of CRISPR technology. Carl shares insights from his recent award trip to Spain and reflects on the importance of mentorship in shaping future scientists. Lastly, he emphasizes the significance of teamwork in advancing research and achieving a work-life balance in the fast-evolving biopharma sector.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
ANECDOTE

Joining Forces Accelerated Progress

  • Carl June recounts joining the Parker Institute in 2015 to unite major cancer centers for cell therapy progress.
  • He says collaborative networks produced findings that likely would not have occurred if teams worked in isolation.
INSIGHT

CRISPR Trials Revealed New Limits

  • Multiplex CRISPR editing in humans proved safe and efficient but revealed limitations like chromosomal translocations.
  • Addressing exhaustion, trafficking, and lack of dream targets is now central for solid tumor cell therapy.
INSIGHT

LNPs Open Multi‑CAR Possibilities

  • Lipid nanoparticle and RNA pooling enable transient multi-CAR expression, offering a path for multi-antigen targeting.
  • Glioblastoma may be the first solid tumor to test multi-CAR or in vivo RNA delivery strategies.
Get the Snipd Podcast app to discover more snips from this episode
Get the app