Experts from around the globe discuss the concept and challenges of platform trials in clinical research. They explore the efficiencies, funding issues, and statistical considerations of transitioning to big team science. The role of patient groups in trial designs and the challenges of educating institutional review boards and securing funding are also highlighted.

Mark Peters and Doug Gould present the OXY-PICU trial results comparing conservative with liberal oxygenation targets in critically ill children. Luregn Schlapbach delivers an independent editorial. Topics discussed include findings of a study on conservative oxygenation, trial design and methodology, organ support analysis, statistical methods, deciding on initial analysis, role of journal editors in implementing study results, and importance of including nurses in ICU discussions.