Summary of the Oxy-Pikyu Trial Presentation

The Oxy-Pikyu trial compared conservative with liberal oxygenation targets in critically ill children receiving invasive mechanical ventilation. The trial found that conservative oxygenation targets led to a small but significant benefit in terms of the duration and severity of organ failure. The trial recruited 2,040 children and demonstrated good adherence to the protocol. The primary outcome, a composite measure of survival and duration of organ support, showed a slight advantage in the conservative oxygen group. Secondary outcomes, such as mortality and length of stay, also favored the conservative oxygen group. The trial highlighted the importance of conducting large-scale randomized controlled trials in pediatric critical care to address the gap in evidence. The findings suggest that a conservative approach to oxygenation may be beneficial for critically ill children on mechanical ventilation.