In this discussion, Bob Kaplan, a collaborator on the 'Studying Studies' series, sheds light on how to navigate the complexities of scientific research. He and Peter dissect various study types, clinical trial phases, and biases that can distort findings. They emphasize the importance of differentiating relative and absolute risk and understanding statistical significance. Kaplan shares practical strategies for reading scientific papers critically and highlights the significance of rigorous study design, particularly in nutrition and drug trials.

In this engaging discussion, Bob Kaplan collaborates with Peter Attia, reflecting on evolving beliefs from their podcast journey. They delve into the transformation of Peter's views on metformin, rapamycin, and deadlifting, emphasizing the importance of adaptability in health perspectives. They also share the joy of Peter’s new puppy, explore the significance of Zone 2 training, and discuss how learning to say 'no' has impacted their lives. With insights on omega-3s and personal updates, this conversation offers a fascinating look at growth through dialogue.

In this “Ask Me Anything” (AMA) episode, Peter answers a wide range of questions from readers and podcast listeners. Bob Kaplan, Peter’s head analyst, asks the questions. This also marks the first video release of the podcast. You can find it on YouTube (https://youtu.be/kzs7GgxR_FQ) and the website (peterattiamd.com/ama03). If you have any questions for the next AMA, please submit them to the AMA section on the website (peterattiamd.com). We discuss: What references ranges does Peter consider too broad on lab tests? [5:30]; What aspect of women’s health is the least studied/understood? [21:15]; What are your thoughts on fasting and ketosis for females? [31:30]; Advice for medical students and residents, how to get through it, and optimize their time while in med school [38:00]; What is Peter’s opinion on the best way to monetize a podcast to make it sustainable? [47:45]; What are you looking to achieve and monitor with your blood glucose monitor? [57:15]; Thoughts on lithium supplementation? [1:08:15]; Insights about berberine? [1:16:00]; Why does Peter take a baby aspirin? What does the science say? [1:19:20]; How do you use HR variability as a metric in your practice and/or in your own personal use? Sleep, pre/post exercise, pre/post eating, every morning readiness? [1:23:25]; With the emergence of “the coconut oil is pure poison” article, can you shed some light on saturated fat in the literature and the types of studies done specifically on coconut oil? [1:38:45]; Would you discuss the recent meta studies that claim that moderate carbohydrate intake may be best for health? [1:40:45]; What is the number one recommendation/habit you would suggest every person add to their daily regimen (besides physical activity) for wholesome health? [1:42:45]; What does it mean if your body has a harder time getting into ketosis via fasting than it used to (testing using a Precision Xtra)? [1:44:15]; Why are you taking Zetia and Lipitor? Are you mitigating risk based on your APOE4? Or is there something else going on? [1:46:10]; What will your book be about and what is the expected release date? [1:47:45]; What are your thoughts on nicotinamide riboside supplementation for longevity? [1:49:30]; Which brand of supplements have you found to be effective? [1:54:30]; Are you currently accepting new patients? And how do I find a ‘Peter Attia clone’ in my area? [1:56:20]; Bob’s personal experience with Peter as a doctor [1:58:45]; Can you tell us more about the latest and best of APOE4? [2:06:15]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook| Twitter| Instagram.

In this discussion, Dom D'Agostino, an expert in ketosis and cancer research, emphasizes the potential of ketogenic diets in reducing cancer therapy toxicity. He talks about the promising applications of hyperbaric oxygen therapy and its therapeutic uses, including possible benefits for COVID-19 patients. Insights on the interplay between glucose and ketones are revealed, alongside the role of vitamin C in enhancing cancer treatment. Additionally, Dom explores how ketosis may impact female health and performance, making a case for its broader applications.

In a deep dive on hot and cold therapy, Bob Kaplan, Peter Attia's head of research, shares insights into the evidence supporting these therapies. They discuss the efficacy of cold therapy for muscle soreness and explore intriguing connections to depression and immune function. Kaplan reveals the potential longevity benefits of dry saunas, critically analyzing the existing literature. They also discuss how stress manifests physically and share personal anecdotes about the challenges of managing time zone changes, adding a relatable touch to their expert conversation.