#103 - Looking back on the first 99 episodes: Strong Convictions, Loosely Held
Apr 6, 2020
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In this engaging discussion, Bob Kaplan collaborates with Peter Attia, reflecting on evolving beliefs from their podcast journey. They delve into the transformation of Peter's views on metformin, rapamycin, and deadlifting, emphasizing the importance of adaptability in health perspectives. They also share the joy of Peter’s new puppy, explore the significance of Zone 2 training, and discuss how learning to say 'no' has impacted their lives. With insights on omega-3s and personal updates, this conversation offers a fascinating look at growth through dialogue.
Peter Attia emphasizes the principle of 'strong convictions loosely held' to encourage open-mindedness and adaptability in scientific discussions.
His reevaluation of metformin illustrates the importance of continuously questioning and updating long-held medical beliefs based on new evidence.
The decision to adopt a dog reflects personal growth and the rewards of embracing change while navigating the challenges of new experiences.
Deep dives
Evolution of Perspectives on Change
The host reflects on the idea of changing one's mind over time, particularly in the context of scientific and medical discussions. Emphasizing the importance of remaining open to new information, the phrase 'strong convictions loosely held' is articulated as a guiding principle. This notion suggests that in fields like medicine, being receptive to evolving evidence is crucial for personal growth and improved outcomes. The discussions serve as a retrospective, highlighting how previous episodes contributed to these shifts in understanding.
Impact of Metformin on Longevity
The host describes a significant change in perspective regarding metformin, a medication initially believed to enhance longevity benefits for healthy individuals. Initially taken for its reputed advantages, evidence accumulated suggesting its utility may be limited primarily to those with metabolic disorders like diabetes. After personal experimentation and further research, the host concluded that metformin might not provide the expected benefits in metabolically healthy people and decided to stop taking it. This reevaluation underscores the need for continual inquiry into long-held beliefs in medicine.
Insights on Rapamycin
The host presents an evolving understanding of rapamycin, a drug previously viewed as beneficial primarily in specific contexts. Initially intrigued by its effects on the immune system and aging, the host acknowledges the complexities surrounding dosing and efficacy. With ongoing research revealing potential applications, particularly in enhancing immune response in older adults, the host now considers rapamycin as a vital part of a personal health strategy. This highlights the importance of not only understanding current literature but also the need for future research on its broader applications.
The Journey of Dog Ownership
Transitioning from apprehension to acceptance, the host recounts the decision to adopt a dog after initially resisting the idea. Through social media encouragement and familial support, the adoption process led to bringing home a puppy named Molly, offering unforeseen companionship and joy. Despite acknowledging the challenges of pet ownership, such as training and time commitment, the host recognizes the profound emotional benefits derived from the experience. This personal anecdote reinforces the theme of embracing change and the rewards that accompany new experiences.
Valuing Time and Learning to Say No
The podcast discusses the importance of learning to say no as a means of safeguarding one’s time and priorities. The host reflects on a personal journey from being overly accommodating to recognizing the necessity of establishing boundaries. Highlighting a recent experience where a potential commitment was declined, the host points out the significance of reflecting on obligations with clarity. This valuable lesson promotes the idea that selectively choosing engagements leads to a more focused and fulfilling life.
In this episode, originally recorded to be the 100th episode of The Drive, Peter discusses topics that he has changed his mind about since starting the podcast as a result of preparing for interviews as well as from the actual conversations. Peter also reviews some of his favorite moments from the first 99 episodes, shares what books he’s currently reading, and much more. Initially scheduled to be released as episode 100, this was delayed due to recent podcasts covering COVID-19.
We discuss:
Definition of “strong convictions loosely held,” and the value in trying to shoot down your own hypotheses [2:20];
Metformin—How Peter’s strong convictions have changed since 2018 [8:00];
Getting a dog—Why Peter caved and how it’s going so far [15:45];
Rapamycin—How Peter’s feelings have evolved, and the questions still needing to be answered [20:45];
Archery, the joy of pursuing mastery, and the importance of stillness [26:50];
Zone 2 training—Why Peter has made it a big component of his exercise regimen [37:30];
Deadlifts—Why Peter now believes it’s extremely beneficial to longevity when done properly [41:45];
Read any good books lately? [50:00];
Baby aspirin for preventing blood clotting—Why Peter no longer takes it, and a few alternative options [53:15];
Generic drugs—How and why Peter’s mind has shifted on generic drugs [55:45];
Omega-3 fatty acids, EPA and DHA—How Peter’s long-held views have changed [58:15];
How Peter got better at saying “no” [1:02:30];
Does Peter have any favorite episodes of The Drive? [1:07:15]; and