JAMA Clinical Reviews
JAMA Editors’ Choice 2023: Clinical Reviews Podcasts
Jan 2, 2024
JAMA editors highlight top 2023 Clinical Reviews podcasts, including cirrhosis management, heart failure treatments, worsening US maternal death rates, and addressing obstetric racism.
24:08
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Quick takeaways
- Cirrhosis symptoms can be managed with pickle juice, taurine, bile acid binders, naltrexone, sleep hygiene, hydroxylsine, melatonin, and prescription therapies for sexual dysfunction.
- SGLT2 inhibitors like dapagliflozin and empagliflozin show promise in reducing heart failure hospitalizations and improving quality of life in patients with heart failure with preserved ejection fraction (HFpEF), but there are contraindications for their use.
Deep dives
Latest Developments in the Treatment of Cirrhosis
Cirrhosis, affecting millions of adults in the U.S., has several common symptoms like muscle cramps, itching, sleep dysfunction, and sexual dysfunction. Treatment options for these symptoms include pickle juice and taurine to relieve muscle cramps, bile acid binders and naltrexone for itching, sleep hygiene and medications like hydroxylsine and melatonin for sleep dysfunction, and prescription therapies for sexual dysfunction. Furthermore, complications of cirrhosis like hepatic encephalopathy, ascites, and varicial bleeding have evidence-based treatments such as lactulose and refaxamine for hepatic encephalopathy, aldosterone antagonists combined with diuretics for ascites, and non-selective beta blockers for varicial bleeding.
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