

Exposing Longevity Supplements: Is NAD+ IV Therapy Worth the Hype? Dr. Matt Kaeberlein
Jun 24, 2025
Dr. Matt Kaeberlein, a leading expert on aging biology, dives into the world of longevity supplements, spotlighting the hype around NAD+ IV therapy. He emphasizes the importance of being skeptical of self-proclaimed longevity experts and discusses the need for reliable information. Kaeberlein also critiques popular wellness trends, advocating for foundational health habits over questionable supplements. Additionally, he explores rapamycin's potential in promoting healthy aging, particularly its effects on ovarian function, and touches on the impact of GLP-1 medications on metabolic health.
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NAD Supplementation Realities
- NAD is crucial for thousands of cellular reactions but direct NAD IVs have unclear benefits.
- NAD precursors like NMN or NR may help some but aren't proven universally effective or superior to cheaper forms like niacin.
Limits of Biological Age Tests
- Biological age can't be quantitatively measured, only correlated markers can.
- Epigenetic clocks estimate risks but don't directly measure biological age itself.
Prioritize Fundamentals Over Trends
- Prioritize fundamentals like healthy diet and regular movement over trendy therapies like ice baths.
- Invest effort in sustainable lifestyle habits that truly impact health.