Bloody Minded Episode 53 - PlateLOTS | Approaching Thrombocytosis
Jul 15, 2025
Explore the curious case of thrombocytosis, where having too many platelets can cause more problems than they solve. Delve into the biology of platelet production and how misleading lab results can complicate diagnoses. Discover the connection between iron deficiency and elevated platelet counts, alongside the role of cytokines and bone marrow issues. Learn about the implications of thrombocytosis and why identifying underlying causes matters. Join a lighthearted yet informative journey into a complex medical phenomenon!
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Defining Thrombocytosis Levels
- Thrombocytosis means having too many platelets, generally above 450x10^9/L in adults.
- Extreme thrombocytosis is usually defined as platelet counts above 1000x10^9/L, prompting hematology referral.
Causes of Thrombocytosis
- Causes of thrombocytosis are increased production, decreased destruction, or redistribution of platelets.
- These three mechanisms explain virtually all causes of any elevated blood cell count.
Check for Spurious Thrombocytosis
- Always check for spurious thrombocytosis by reviewing a blood film when counts are unexpectedly high.
- Automated counters can miscount red cell fragments, cryoglobulin crystals, or bacteria as platelets.