Bloody Minded

Dr. Sara Ng, a consultant haematologist specializing in thrombosis, tackles the challenging topic of managing thrombosis when platelet counts are dangerously low. She shares spine-tingling clinical cases, offering insights into acute conditions like pulmonary embolism and thrombocytopenia. Dr. Ng discusses anticoagulation strategies, the role of thrombectomy, and risks associated with IVC filters in cancer patients. Her practical approach emphasizes the importance of thorough assessments and prevention, making this discussion a must-listen for healthcare professionals.

In this enlightening discussion, the hosts dive into activated protein C resistance testing, exploring its role in diagnosing thrombophilia. They tackle the complexities of Factor V Leiden and the impact of prothrombin gene mutations, emphasizing the significance of molecular testing methods. Alongside their scientific revelations, the crew adds a sprinkle of humor with pop culture references, making for an engaging and informative session. They also warn against ordering MTHFR testing for thrombophilia, highlighting key insights in lab practices.

Explore the fascinating world of thrombophilia testing with engaging insights from laboratory experts. Discover the nuances of lupus anticoagulant testing and how various assays differentiate between deficiencies. Learn about the biology of Protein C and S, including their functions and the intricacies of testing methods like ELISA and chromogenic assays. The discussion dives into the effects of anticoagulants on test results and debunks common myths around coagulation. Buckle up for a thrilling journey through the emerald lab!

Ever wondered about thrombophilia testing? Dive into an exploration of its importance, including a passionate rant about inappropriate testing practices. Discover the distinctions between inherited and acquired thrombophilias, and why MTHFR testing should be avoided. The hosts discuss key inherited conditions like Factor V Leiden and the prothrombin gene mutation, along with the clinical ramifications of test results. Hear expert insights on when to test and how these results affect patient care—it's a riveting blend of science, history, and humor!

We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, uterine and testicular thrombi it's clots as far as the eye can see (and those it can't like CRVO!)Timestamps:0:58 - ROADTRIP4:07 - CVST11:07 - CVST - Treatment15:36 - Lemierre's17:50 - CRVO24:36 - Splanchnic Thrombi34:45 - Renal Vein Thrombi39:41 - Uterine Vein Thrombus42:09 - Ovarian Vein44:42 - Testicular Vein46:35 - TakehomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Dive into the intricate world of superficial thrombophlebitis, where beauty meets the risk of clots! Learn about the key superficial veins and the difference between thrombosis and phlebitis. Discover surprising syndromes linked to SVT and the risk factors that can contribute to this condition. The hosts also discuss diagnostic strategies, initial conservative treatments, and when to consider anticoagulation. Plus, find out how pregnancy affects SVT management. Stay informed and entertained on this fascinating journey through vascular health!

Explore the fascinating world of D-dimers, starting with their role as fibrin degradation products in clotting dynamics. Discover how various assays, like ELISA and POCT, measure D-dimer levels and what those results mean clinically. The hosts break down the differences between DDU and FEU units, and their implications in diagnosis. Learn about D-dimer’s connections to cancer and other conditions that can elevate levels, as well as its significance in pregnancy and aortic dissection diagnosis. It's a deep dive into the complexity of this crucial diagnostic tool!

Join the lively discussion as the hosts delve into pulmonary embolism, exploring its clinical importance and risk factors. They share common signs and symptoms, from dyspnea to ECG changes, and break down essential diagnostic tests like CTPA and D-dimer criteria. Treatment strategies are covered, including anticoagulation and reperfusion therapies, with special attention to PE during pregnancy. Wrap it up with key take-home points that highlight the significance of timely diagnosis and management.

Dive deep into the world of DVTs as the hosts unravel the mysteries of extremity clots! Discover why lower limb DVTs are a major concern, and learn about the anatomy of veins involved. Understand the dangers of phlegmasia and the critical blood tests needed before anticoagulation. Explore the management strategies for both below-knee and proximal DVTs, plus the implications of May-Thurner syndrome. Finally, get insights on upper limb DVTs, including causes and when to anticoagulate. It's a must-listen for those wanting to master clot care!

Explore the fascinating world of venous thromboembolism as hosts dive into clots, clotting processes, and risk factors. Discover the intriguing history behind Virchow's triad and how it influences clinical assessments. Learn the key differences between arterial and venous clots, along with practical categorization of VTE risk factors. The discussion also covers effective management strategies, including anticoagulation choices and the implications of thrombosis history. Embark on this riveting journey through the pathways of clotting and care!