Bloody Minded

Delve into the festive unraveling of Christmas Disease, also known as haemophilia B. Discover the fascinating history behind its name, tied to patient Stephen Christmas. Learn about the evolution of coagulation studies and the unique role of the Christmas factor. The hosts also tackle modern treatments, including groundbreaking gene therapy advancements. Plus, enjoy a dose of humor with Christmas-themed songs, making complex medical topics both engaging and entertaining!

Dr. Caroline Dix, a Consultant haematologist at the Austin Hospital, delves into the complexities of thrombotic disorders. She explains the nuances of Cerebral Venous Sinus Thrombosis (CVST), highlighting risk factors for young women and the critical role of anticoagulation even in the presence of hemorrhage. Caroline also breaks down antithrombin deficiency, exploring types, diagnostic tests, and management strategies, including tailored anticoagulant choices and the importance of monitoring during pregnancy. Her insights make thrombosis fascinating!

Dr. Sara Ng, a consultant haematologist specializing in thrombosis, tackles the challenging topic of managing thrombosis when platelet counts are dangerously low. She shares spine-tingling clinical cases, offering insights into acute conditions like pulmonary embolism and thrombocytopenia. Dr. Ng discusses anticoagulation strategies, the role of thrombectomy, and risks associated with IVC filters in cancer patients. Her practical approach emphasizes the importance of thorough assessments and prevention, making this discussion a must-listen for healthcare professionals.

In this enlightening discussion, the hosts dive into activated protein C resistance testing, exploring its role in diagnosing thrombophilia. They tackle the complexities of Factor V Leiden and the impact of prothrombin gene mutations, emphasizing the significance of molecular testing methods. Alongside their scientific revelations, the crew adds a sprinkle of humor with pop culture references, making for an engaging and informative session. They also warn against ordering MTHFR testing for thrombophilia, highlighting key insights in lab practices.

Explore the fascinating world of thrombophilia testing with engaging insights from laboratory experts. Discover the nuances of lupus anticoagulant testing and how various assays differentiate between deficiencies. Learn about the biology of Protein C and S, including their functions and the intricacies of testing methods like ELISA and chromogenic assays. The discussion dives into the effects of anticoagulants on test results and debunks common myths around coagulation. Buckle up for a thrilling journey through the emerald lab!

Ever wondered about thrombophilia testing? Dive into an exploration of its importance, including a passionate rant about inappropriate testing practices. Discover the distinctions between inherited and acquired thrombophilias, and why MTHFR testing should be avoided. The hosts discuss key inherited conditions like Factor V Leiden and the prothrombin gene mutation, along with the clinical ramifications of test results. Hear expert insights on when to test and how these results affect patient care—it's a riveting blend of science, history, and humor!

Join an intriguing exploration of unusual clots like cerebral venous sinus thrombosis (CVST) and splanchnic vein thrombosis. Learn about the surprising causes and complex management strategies for these rare conditions. The hosts discuss critical symptoms, diagnostic imaging, and effective treatment options, including anticoagulation and surgery. They even touch on the fascinating Lemierre syndrome and the connection between ovarian thrombosis and pregnancy. Prepare for a wild ride through the lesser-known aspects of human plumbing!

Dive into the intricate world of superficial thrombophlebitis, where beauty meets the risk of clots! Learn about the key superficial veins and the difference between thrombosis and phlebitis. Discover surprising syndromes linked to SVT and the risk factors that can contribute to this condition. The hosts also discuss diagnostic strategies, initial conservative treatments, and when to consider anticoagulation. Plus, find out how pregnancy affects SVT management. Stay informed and entertained on this fascinating journey through vascular health!

Explore the fascinating world of D-dimers, starting with their role as fibrin degradation products in clotting dynamics. Discover how various assays, like ELISA and POCT, measure D-dimer levels and what those results mean clinically. The hosts break down the differences between DDU and FEU units, and their implications in diagnosis. Learn about D-dimer’s connections to cancer and other conditions that can elevate levels, as well as its significance in pregnancy and aortic dissection diagnosis. It's a deep dive into the complexity of this crucial diagnostic tool!

Join the lively discussion as the hosts delve into pulmonary embolism, exploring its clinical importance and risk factors. They share common signs and symptoms, from dyspnea to ECG changes, and break down essential diagnostic tests like CTPA and D-dimer criteria. Treatment strategies are covered, including anticoagulation and reperfusion therapies, with special attention to PE during pregnancy. Wrap it up with key take-home points that highlight the significance of timely diagnosis and management.