The Metabolic Link
The Mitochondrial Link to Mental Illness | Ana Andreazza, PhD | The Metabolic Link Ep.63
Mar 11, 2025
Dr. Ana Andreazza, a Professor at the University of Toronto and an expert in mitochondrial function, discusses the revolutionary connections between mitochondria and mental health. She highlights her pioneering research on mitochondrial dysfunction in psychiatric disorders, particularly bipolar disorder. Delving into innovative models like 3D brain organoids, she reveals how mitochondrial health impacts mood and metabolism. The conversation also covers potential treatments, including mitochondrial transplantation and the role of substances like metformin and C15 fatty acids.
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Quick takeaways
- Mitochondrial dysfunction is significantly linked to psychiatric disorders like bipolar disorder, affecting neurotransmitter signaling and mood regulation.
- Innovative 3D brain organoid models are being utilized to study the implications of mitochondrial dysregulation on cellular function and therapeutic strategies.
Deep dives
Exploring Mitochondrial Dysfunction and Mood Disorders
Mitochondrial dysfunction has been linked to various psychiatric disorders, particularly mood disorders such as bipolar disorder. Research indicates a dysregulation in mitochondrial genes among patients with these disorders, highlighting the potential role of mitochondrial health in affecting neurotransmitter signaling. The use of innovative 3D brain organoid models allows for the examination of how mitochondrial dysregulation impacts neurotransmission and cellular function in such conditions. These advancements are paving the way for personalized treatment strategies that leverage mitochondrial insights to enhance therapeutic outcomes in mood disorders.
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