How Fast Are You Aging? Understanding the Dunedin Pace and the Power of Epigenetics - Episode 262
Nov 21, 2024
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Hannah Went, co-founder of TrueAge and a pioneer in epigenetic clocks, dives into the groundbreaking world of biological aging. She explains how epigenetics can accurately measure biological age and discusses tools like the Dunedin Pace and GrimAge clocks. The conversation highlights the crucial role of caloric restriction in impacting aging metrics and the multifaceted nature of aging. Went also shares insights on the future of epigenetic research and the importance of actionable steps for health optimization.
Epigenetic clocks like GrimAge utilize biological markers to predict health outcomes and mortality risk, emphasizing the quality of aging over mere chronological age.
The Dunedin Pace metric reveals significant variations in biological aging rates among individuals, necessitating a comprehensive understanding of aging as a multifactorial process.
Deep dives
The Development of Predictive Aging Clocks
A comprehensive analysis of clinical lab variables and metabolites has led to the creation of a highly predictive biological aging clock, known as omic MH. This innovative approach measures numerous biological markers, which provides insights into the aging process and enhances predictions related to health and longevity. The introduction of epigenetic biomarker proxies (EBPs) adds depth by offering personalized reasons for variations in aging rates. Overall, this advancement aims to help individuals understand their aging trajectory and highlights the factors that might accelerate or decelerate that process.
Understanding Epigenetic Clocks
Epigenetic clocks are distinct biomarkers that assess an individual's biological age by examining patterns of DNA methylation. Initially, first-generation clocks could predict chronological age and associated health outcomes better than traditional chronological markers. As the field has evolved, second-generation clocks, like the Grim Age, have integrated lifestyle factors and additional biomarkers to improve predictive accuracy. This shift towards biological age metrics emphasizes the importance of understanding not just how long one has lived, but rather the quality of their health and longevity.
The Significance of Multi-Omic Age Measurement
The use of multi-omic data has elevated the potential for predictive aging assessments, combining diverse biological data for a comprehensive overview. By examining clinical lab variables, metabolites, and proteins, this multi-ome approach enhances the accuracy of age measurement and personal health insights. It allows for the identification of specific targets for intervention, helping individuals implement actionable changes to improve their well-being. This method represents a significant milestone in the ongoing quest to understand and manipulate the aging process effectively.
Unraveling the Complexity of Aging
The complexities of aging are underscored by the dimensional nature of biological age, which can vary across different bodily systems and functions. Recently developed metrics, such as the Deneendon Pace, highlight the variations in how individuals age, indicating that biological aging can differ significantly from chronological aging. Additionally, the need for a multidimensional approach to aging assessment calls attention to the limitations of relying on single metrics for health evaluations. A holistic understanding of the different facets of aging could lead to more personalized and effective health optimization strategies.
In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Hannah Went, co-founder of TrueAge, a leading omics age company. They discuss the significance of epigenetics in understanding biological age, the predictive power of various aging clocks, and the advancements in measuring biological age through multi-omics approaches. The conversation also covers the impact of interventions like caloric restriction on aging metrics, the Dunedin Pace as a new metric for biological aging, and the complexity of aging as a multifactorial process. Went shares insights into the future of epigenetic research and the importance of actionable insights for health optimization. For the audience: * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/ Takeaways * Epigenetic markers can predict chronological age with high accuracy. * GrimAge is a new clock that estimates mortality risk. * Multi-omics approaches provide a comprehensive view of aging. * Caloric restriction significantly impacts biological age. * Dunedin Pace measures the rate of biological aging. * Aging is a complex, multifactorial process. * Understanding what tests do not measure is crucial. * New biomarkers for aging are being developed and validated. Chapters 00:00 Introduction to Omics Age and TrueAge 04:12 The Evolution of Epigenetic Clocks 07:55 Integrating Lifestyle Factors in Omics Age Testing 10:14 Predicting Disease Risk and Mortality with Omics Age 13:27 Reversing Biological Age with Interventions 16:42 Actionable Insights from Omics Age Testing 26:30 Exploring the Impact of Caloric Restriction on Aging 29:08 Understanding the Dunedin Pace as a Measure of Biological Aging 33:32 The Complexity of Aging and the Limitations of Single Metrics 35:24 Epigenetic Biomarker Proxies: A Comprehensive Approach to Aging 43:59 Cell Reprogramming and its Implications for Aging 49:24 Goodbye Learn more about TruAge and/or contact them: Email: hannah@trudiagnostic.com Website: https://www.trudiagnostic.com/ Facebook: https://www.facebook.com/TruDiagnostic/ Instagram: https://www.instagram.com/trudiagnosticofficial/ X: https://x.com/TruDiagnostic YouTube: https://www.youtube.com/c/trudiagnostic TikTok: https://www.tiktok.com/@trudiagnostic?is_from_webapp=1&sender_device=pc LinkedIn: https://www.linkedin.com/company/trudiagnostic/ Reach out to us! Website: https://gladdenlongevity.com/ Email: podcast@gladdenlongevity.com Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw
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