Gladden Longevity Podcast -- formerly Living Beyond 120 cover image

Gladden Longevity Podcast -- formerly Living Beyond 120

How Fast Are You Aging? Understanding the Dunedin Pace and the Power of Epigenetics - Episode 262

Nov 21, 2024
Hannah Went, co-founder of TrueAge and a pioneer in epigenetic clocks, dives into the groundbreaking world of biological aging. She explains how epigenetics can accurately measure biological age and discusses tools like the Dunedin Pace and GrimAge clocks. The conversation highlights the crucial role of caloric restriction in impacting aging metrics and the multifaceted nature of aging. Went also shares insights on the future of epigenetic research and the importance of actionable steps for health optimization.
50:26

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Epigenetic clocks like GrimAge utilize biological markers to predict health outcomes and mortality risk, emphasizing the quality of aging over mere chronological age.
  • The Dunedin Pace metric reveals significant variations in biological aging rates among individuals, necessitating a comprehensive understanding of aging as a multifactorial process.

Deep dives

The Development of Predictive Aging Clocks

A comprehensive analysis of clinical lab variables and metabolites has led to the creation of a highly predictive biological aging clock, known as omic MH. This innovative approach measures numerous biological markers, which provides insights into the aging process and enhances predictions related to health and longevity. The introduction of epigenetic biomarker proxies (EBPs) adds depth by offering personalized reasons for variations in aging rates. Overall, this advancement aims to help individuals understand their aging trajectory and highlights the factors that might accelerate or decelerate that process.

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