Exploring Epigenetics and Cellular Reprogramming in Aging Research

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Hannah Went, co-founder of TrueAge, a leading omics age company. They discuss the significance of epigenetics in understanding biological age, the predictive power of various aging clocks, and the advancements in measuring biological age through multi-omics approaches. The conversation also covers the impact of interventions like caloric restriction on aging metrics, the Dunedin Pace as a new metric for biological aging, and the complexity of aging as a multifactorial process. Went shares insights into the future of epigenetic research and the importance of actionable insights for health optimization. For the audience: * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/ Takeaways * Epigenetic markers can predict chronological age with high accuracy. * GrimAge is a new clock that estimates mortality risk. * Multi-omics approaches provide a comprehensive view of aging. * Caloric restriction significantly impacts biological age. * Dunedin Pace measures the rate of biological aging. * Aging is a complex, multifactorial process. * Understanding what tests do not measure is crucial. * New biomarkers for aging are being developed and validated. Chapters 00:00 Introduction to Omics Age and TrueAge 04:12 The Evolution of Epigenetic Clocks 07:55 Integrating Lifestyle Factors in Omics Age Testing 10:14 Predicting Disease Risk and Mortality with Omics Age 13:27 Reversing Biological Age with Interventions 16:42 Actionable Insights from Omics Age Testing 26:30 Exploring the Impact of Caloric Restriction on Aging 29:08 Understanding the Dunedin Pace as a Measure of Biological Aging 33:32 The Complexity of Aging and the Limitations of Single Metrics 35:24 Epigenetic Biomarker Proxies: A Comprehensive Approach to Aging 43:59 Cell Reprogramming and its Implications for Aging 49:24 Goodbye Learn more about TruAge and/or contact them: Email: hannah@trudiagnostic.com Website: https://www.trudiagnostic.com/ Facebook: https://www.facebook.com/TruDiagnostic/ Instagram: https://www.instagram.com/trudiagnosticofficial/ X: https://x.com/TruDiagnostic YouTube: https://www.youtube.com/c/trudiagnostic TikTok: https://www.tiktok.com/@trudiagnostic?is_from_webapp=1&sender_device=pc LinkedIn: https://www.linkedin.com/company/trudiagnostic/ Reach out to us! Website: https://gladdenlongevity.com/ Email: podcast@gladdenlongevity.com Facebook: https://www.facebook.com/Gladdenlongevity/ Instagram: https://www.instagram.com/gladdenlongevity/?hl=en LinkedIn: https://www.linkedin.com/company/gladdenlongevity YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw

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• Production & Independence

The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas.

Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements.

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The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content.

The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options.

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Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team.

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