Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Jeff Boyd, founder of MTE and a leader in the new wave of performance supplements. With a background in data-driven wellness and a decade of experience optimizing human performance without caffeine or sugar, Jeff breaks down the science of nootropics, adaptogens, and smart nutrient stacking. His work focuses on self-quantification, nervous system regulation, and sustainable energy for founders, athletes, and high performers.
Together, they explore why 85% of supplements are designed to fail, how to activate mitochondria for real results, and what it means to biohack your biology smarter, not harder. This isn’t just about supplements. It’s about reclaiming your energy, upgrading your brain, and aligning your stack with how your body actually works. You’ll also hear how fasting, sleep optimization, and even subtle neurohacking protocols support long-term resilience and better decision-making.
You’ll Learn:
• The real reason most supplements don’t absorb and how to fix it
• How to build a caffeine-free stack that fuels energy, mood, and clarity
• The latest in adaptogens, nootropics, and functional medicine
• How to align your supplement timing with circadian biology and ketosis
• Why “clean labels” often mean nothing
• How emotional regulation and neurotransmitters shape performance
• Tools for self-quantification and supplement personalization
This is essential listening for anyone serious about biohacking, longevity, smarter supplementation, mitochondrial health, sleep optimization, emotional resilience, and conscious human performance.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• MTE website – www.getmte.com
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:13 Saffron Benefits
• 02:26 Medicinal Herbs
• 04:12 Supplement Formulation
• 13:16 Theanine & GABA
• 20:06 Adaptogens & Performance
• 23:23 Stress & Muscle Growth
• 24:03 Parenting & Energy
• 27:47 Nervous System for Kids
• 35:15 Sleep for Families
• 36:41 Wrap-Up & Offers
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The Human Upgrade with Dave Asprey 
