Siim Land Podcast #466 Ultimate Supplement Tier List 2025 - 100 Supplements Ranked Worst to Best
Aug 16, 2025
Dive into a detailed ranking of over 100 supplements for 2025, from the highly praised methylated B vitamins to the controversial resveratrol. Discover the health benefits of intriguing options like sulforaphane, ashwagandha, and NAC. The evaluation covers efficacy, risks, and specific populations who might benefit most. Plus, learn about the importance of probiotics tailored to individual gut health. Unpack which supplements truly stand out for longevity and metabolic support.
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Ca-AKG Shows Early Longevity Signals
- Calcium alpha-ketoglutarate shows some promise in animal lifespan studies and DNA methylation clocks in humans.
- Siim Land rates current human evidence as limited and places it in an OK tier pending more trials.
NAD Boosters Differ In Evidence
- NR and NMN both raise NAD but differ in evidence and effects across species.
- Siim ranks NR above Ca-AKG and NMN slightly below NR based on available human and animal data.
Niacinamide: Skin Benefits, HDL Limits
- Niacinamide raises NAD and has clear skin-protective effects, especially against UV.
- High-dose niacin raises HDL but doesn't reduce heart disease events and can stress the liver.