Mayo Clinic Talks
What’s New with C. Difficile?
Aug 29, 2023
Dr. Sehil Khanna discusses the risk factors and symptoms of C. difficile infection, including the role of antibiotic exposure and the spread of the infection in hospitals and nursing facilities. This chapter also covers the potential complications of the infection and the recommended treatments, including vancomycin and fidaxomicin. Furthermore, it explores options for recurrent infections such as antibiotic regimens, bezel or toxin map monoclonal antibody, and fecal microbiota transplantation. In addition, learn about the key points in diagnosing and treating C. difficile infection, including the importance of risk factors and obtaining a thorough patient history. Discover the recommended first-line treatments and the availability of bezlotoxumab for recurrence prevention, as well as the potential of microbiome-based therapies in the future.
26:16
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Quick takeaways
- C. difficile infection can be spread through contact with contaminated surfaces or from person to person, especially in healthcare settings.
- The first-line treatment for C. difficile infection is a 10-day course of vancomycin or fidaxomicin, and fecal microbiota transplantation (FMT) can be considered for multiple recurrent infections.
Deep dives
Risk Factors for Acquiring C. difficile Infection
People at risk for acquiring C. difficile infection include those who have received antibiotics, especially broad-spectrum antibiotics, people over the age of 65, individuals in hospitals or nursing care facilities, and those with cancer, immunosuppression, chronic kidney disease, or using acid-reducing medications.
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