Dr. Sehil Khanna discusses the risk factors and symptoms of C. difficile infection, including the role of antibiotic exposure and the spread of the infection in hospitals and nursing facilities. This chapter also covers the potential complications of the infection and the recommended treatments, including vancomycin and fidaxomicin. Furthermore, it explores options for recurrent infections such as antibiotic regimens, bezel or toxin map monoclonal antibody, and fecal microbiota transplantation. In addition, learn about the key points in diagnosing and treating C. difficile infection, including the importance of risk factors and obtaining a thorough patient history. Discover the recommended first-line treatments and the availability of bezlotoxumab for recurrence prevention, as well as the potential of microbiome-based therapies in the future.