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Sigma Nutrition Radio
IGF-1 and Diet: Cause For Concern? (SNP36)
Jan 8, 2025
Alan Flanagan, an expert in chronobiology and nutrition, dives into the intricate relationship between IGF-1 and diet. They discuss how IGF-1 impacts growth, metabolic health, and its controversial links to cancer and cognitive decline. Listen in as they explore the challenges of using IGF-1 as a biomarker and the complexities of dietary influences on its levels. Flanagan also unpacks the nuances between total and free IGF-1, and what this means for diet and longevity.
21:56
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Quick takeaways
- IGF-1, influenced by diet and especially protein intake, plays a complex role in growth and potential cancer risks.
- The challenges in using IGF-1 as a reliable biomarker underscore the need for cautious interpretation of its health implications.
Deep dives
Understanding IGF-1 and Its Dietary Connections
IGF-1, or insulin-like growth factor 1, is primarily synthesized in the liver and is closely regulated by growth hormone levels. Its concentrations can significantly be influenced by diet, particularly protein intake, with specific dairy proteins shown to stimulate IGF-1 levels. The conversation surrounding IGF-1 often focuses on the types of protein consumed, distinguishing between animal and plant sources. This distinction is critical due to the hypothesis that higher intakes of animal protein may correlate with elevated IGF-1 levels, potentially leading to increased health risks such as cancer.
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