Science Friday Scientists Create Glowing ‘RNA Lanterns’ With Bioluminescence
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Feb 6, 2025 In this enlightening discussion, Dr. Andrej Lupták and Dr. Jennifer Prescher, both professors at UC Irvine, delve into the fascinating world of bioluminescent RNA lanterns. They explain how their groundbreaking technology uses firefly enzymes to visualize RNA dynamics in real-time, potentially illuminating processes like viral replication and memory formation. The duo shares their decade-long journey filled with challenges and teamwork in developing this innovative tool, which promises to advance research in viral studies and neurobiology.
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RNA's Role
- RNA is the first molecule made when DNA's genetic information is used.
- It's the initial step in gene expression, like a middle manager delegating tasks.
RNA Lanterns
- Scientists attached a bioluminescent enzyme to RNA, creating a "lantern".
- This allows them to track RNA in real-time, similar to how astronomers track stars.
Non-Interference
- Researchers ensured the "lantern" doesn't interfere with RNA function.
- They attached it to a non-functional part of the RNA molecule.