Every year, billions of dollars are funneled into Alzheimer’s research. And yet, so far, there’s no treatment that’s been able to reverse the disease, or even meaningfully slow the cognitive decline of patients.Part of the reason is that the disease is complex, and brain disorders are notoriously difficult to understand.But in a new book, an investigative science reporter makes the case that there’s another reason progress toward Alzheimer’s treatments has stalled: scientific fraud.Host Flora Lichtman talks with Charles Piller, investigative journalist at Science and author of the book Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s.Read an excerpt of Doctored at sciencefriday.com.Transcripts for each segment will be available after the show airs on sciencefriday.com.   Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Bill Tripp, a member of the Karuk tribe and director of natural resources, shares insights on traditional fire management practices that date back centuries. He discusses how the tribe collaborates with other organizations to implement controlled burns, emphasizing their ecological and cultural significance. Tripp highlights the challenges modern wildfire management faces and the urgent need to revive Indigenous techniques to restore ecological balance and combat wildfire risks. Their historical relationship with fire is presented as a model for contemporary practices.

Dr. Jamie Hartmann-Boyce, an Assistant Professor at UMass Amherst, dives into the complex world of vaping and smoking cessation. She discusses the effectiveness of e-cigarettes compared to traditional methods like patches. The conversation also uncovers the risks of dual use—mixing smoking with vaping—and common misconceptions about vaping's dangers. Moreover, Jamie sheds light on the striking differences in health risks between e-cigarettes and traditional cigarettes, all while emphasizing the urgent need for more research in this evolving field.

Joining the discussion is Will Douglas Heaven, Senior Editor for AI at MIT Technology Review, who sheds light on DeepSeek’s groundbreaking AI developments. The conversation humorously contrasts how ancient human ancestor Lucy would fare on a treadmill against modern humans. Experts also tackle the impact of data removal from the CDC and the NIH, emphasizing its consequences for public health research. Lastly, they explore the competitive landscape between DeepSeek and established AI models, revealing its innovative edge.

In this enlightening discussion, Dr. Andrej Lupták and Dr. Jennifer Prescher, both professors at UC Irvine, delve into the fascinating world of bioluminescent RNA lanterns. They explain how their groundbreaking technology uses firefly enzymes to visualize RNA dynamics in real-time, potentially illuminating processes like viral replication and memory formation. The duo shares their decade-long journey filled with challenges and teamwork in developing this innovative tool, which promises to advance research in viral studies and neurobiology.

Dr. Shohini Ghose, a leading quantum physicist and professor at Wilfrid Laurier University, discusses the exciting advancements in quantum computing as we approach 2025. She highlights Google's groundbreaking achievement that solved a complex problem in minutes and explains how traditional and quantum computing will coexist. Ghose also examines the global investment race in quantum technology and its implications for fields like cryptography and everyday encryption, emphasizing the transformative potential that lies ahead.

Dr. Danny Glavin, a senior scientist at NASA, and Dr. Dante Lauretta, a planetary scientist leading the OSIRIS-REx mission, delve into the groundbreaking findings from asteroid Bennu. They discuss the discovery of organic molecules and essential amino acids that could suggest origins of life. The fascinating chirality of amino acids challenges previous theories. They also highlight the meticulous efforts to prevent sample contamination, revealing significant implications for understanding life's building blocks and the search for extraterrestrial life.

Dr. Rima Habre, an environmental health expert from USC, and Dr. Mark Wilson, director of exposure science at CIRI, dive into the aftermath of urban fires in Los Angeles. They discuss the toxic residues left behind, particularly focusing on hazardous materials like asbestos and benzene. The conversation highlights the urgent need for thorough cleanup and proper safety gear, especially for vulnerable populations. They also explore the challenges of understanding the long-term health risks from these toxins, emphasizing the importance of effective research and public health awareness.

Charles Berquist, a senior producer at SciFri, and Niamh Mullins, a psychiatric genomics expert, dive into the recent discovery of the H5N9 bird flu strain in California. They discuss its implications for public health and the potential threat of viral reassortment. Switching gears, Niamh shares groundbreaking findings linking 298 genomic regions to bipolar disorder, unraveling its complex genetics and paving the way for improved treatments. The conversation also hints at the intriguing connections between genetics, gut health, and mental wellness.

Explore how people in the coldest places thrive in winter by adopting a positive mindset. Health psychologist Dr. Kari Leibowitz shares insights from Norway, highlighting cultural adaptations and practical strategies like saunas and cold plunges. The discussion delves into overcoming the winter blues with personal stories and playful approaches. Listeners join in to brainstorm uplifting catchphrases, aiming to rebrand winter as a season of joy rather than dread.