Illuminating RNA: Bioluminescence in Cell Biology

The inner workings of our bodies, particularly what’s happening inside our cells, can be kind of a black box—with countless tiny molecules constantly working and churning to keep us alive. A new technology that blends bioluminescence with cellular machinery may shine some light on the details of their comings and goings and interactions that can be hazy.

Scientists had the bright idea to take that same enzyme that makes fireflies glow and tie it to RNA, the molecule that reads the genetic information in DNA. This developing technology has been used on mice, with the hope that these light-up molecules can help illuminate how viruses replicate or even how memories form in the brain.

Flora Litchtman talks with Dr. Andrej Lupták, professor of pharmaceutical sciences at the University of California Irvine and Dr. Jennifer Prescher, professor of chemistry at the University of California Irvine, about their research on the topic.

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