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ACR Journals On Air
Here Comes the Sun
Aug 22, 2023
Dr. J. Michelle Kahlenberg, an expert in Rheumatology and cutaneous lupus, discusses photosensitivity in lupus patients and the surprising findings of their study on the regulation of photosensitivity by the Hippo Pathway in Lupus Skin. They also explore epigenetic modifications in lupus, the impact of gardening, navigating the Valley of Death in research, and the parallels between farm life and managing a research lab.
25:35
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Quick takeaways
- Epigenetic modifications in lupus patients' DNA contribute to photosensitivity and skin inflammation.
- Activation of the hippo pathway in lupus keratinocytes leads to increased apoptosis and photosensitivity, offering new treatment possibilities.
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Epigenetic Modifications in Lupus Skin
Epigenetic modifications in the DNA of keratinocytes in lupus patients result in more pro-inflammatory cells in the skin. These modifications are heritable, persistent, and contribute to increased photosensitivity and skin inflammation.
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