Wild Health Podcast 480 | Dr. Jeff Graham | Neurodegenerative Disease & Metabolic Dysfunction: Healthspan Series, Part 3
9 snips
Jul 23, 2025 
Join Dr. Jeff Graham, Medical Director at Wild Health and a precision medicine expert, as he dives into the critical relationship between neurodegenerative diseases and metabolic dysfunction. He discusses key early detection strategies, the significant impact of genetics like APOE-4 on Alzheimer’s risk, and lifestyle interventions for brain health. The conversation also covers innovative treatments like GLP-1 medications and the importance of metabolic health in cognitive decline, equipping listeners with tools for a healthier future.
AI Snips
Chapters
Books
Transcript
Episode notes
Early Onset of Neurodegenerative Diseases
- Neurodegenerative diseases can start 10 to 20 years before symptoms appear.
- Early detection is possible now with new technologies assessing cognitive decline markers.
Screen Metabolic Dysfunction First
- Start by screening for metabolic dysfunction in at-risk patients.
- Use labs like fasting insulin, CRP, A1C, and omega-3 index to assess brain health.
Advanced Brain Imaging and Biomarkers
- Use advanced imaging like PET scans or neuroquant MRIs when available.
- Check blood biomarkers like phosphorylated tau and neurofilament light chain for early brain pathology.
