Lift Free And Diet Hard with Andrew Coates

#371 Dr. Spencer Nadolsky - Food Noise, GLP-1 Drugs, and Why Obesity Is So Prevalent

Jun 10, 2025
Dr. Spencer Nadolsky, an industry-leading obesity physician and social media’s 'meme doctor', shares insightful perspectives on the obesity crisis. He discusses the impact of genetics versus environment on obesity and the role of GLP-1 medications in appetite regulation. The conversation dives into the effects of ultra-processed foods and reveals misconceptions about LDL cholesterol risks. He also sheds light on lipedema, a condition affecting many women, and tackles the ethical concerns surrounding pharmaceutical prescription practices.
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INSIGHT

Genetics and Environment Roles

  • Obesity is driven by both genetics and environment, but environment is the primary accelerator.
  • Genetics "load the gun" while environment "pulls the trigger" on obesity prevalence.
INSIGHT

Appetite Dysregulation Dominates

  • Most obesity-related genetics influence appetite regulation in the central nervous system.
  • Appetite dysregulation is a more significant factor than insulin in obesity genetics.
INSIGHT

GLP-1 Meds Showcase Appetite Disease

  • New GLP-1 medications reveal obesity as a disease of appetite dysregulation.
  • These drugs diminish food cravings and hunger, showing people what a regulated appetite feels like.
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