Lift Free And Diet Hard with Andrew Coates #371 Dr. Spencer Nadolsky - Food Noise, GLP-1 Drugs, and Why Obesity Is So Prevalent
Jun 10, 2025
Dr. Spencer Nadolsky, an industry-leading obesity physician and social media’s 'meme doctor', shares insightful perspectives on the obesity crisis. He discusses the impact of genetics versus environment on obesity and the role of GLP-1 medications in appetite regulation. The conversation dives into the effects of ultra-processed foods and reveals misconceptions about LDL cholesterol risks. He also sheds light on lipedema, a condition affecting many women, and tackles the ethical concerns surrounding pharmaceutical prescription practices.
AI Snips
Chapters
Books
Transcript
Episode notes
Genetics and Environment Roles
- Obesity is driven by both genetics and environment, but environment is the primary accelerator.
- Genetics "load the gun" while environment "pulls the trigger" on obesity prevalence.
Appetite Dysregulation Dominates
- Most obesity-related genetics influence appetite regulation in the central nervous system.
- Appetite dysregulation is a more significant factor than insulin in obesity genetics.
GLP-1 Meds Showcase Appetite Disease
- New GLP-1 medications reveal obesity as a disease of appetite dysregulation.
- These drugs diminish food cravings and hunger, showing people what a regulated appetite feels like.
