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ACR Journals On Air
The Scleroderma Cancer Connection
Apr 2, 2024
Dr. Ami A Shah from Johns Hopkins discusses the link between Scleroderma and cancer risk, highlighting specific antibody profiles as indicators. The podcast explores genetic alterations, biomarkers, and collaborations in examining this connection. Dr. Shah also shares her journey to becoming a physician-scientist, mentoring others in Scleroderma research through a K24 grant, and emphasizing leadership and collaboration in the Rheumatology Division at Johns Hopkins.
25:18
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Quick takeaways
- Specific antibodies in scleroderma patients can indicate varying levels of cancer risk, with some antibodies linked to higher risks.
- Analyzing combinations of scleroderma autoantibodies can help predict personalized cancer risks for patients.
Deep dives
The Link Between Cancer and Scleroderma
Patients with scleroderma can have an increased risk of cancer, especially those with specific antibodies like anti-RNA polymerase 3. The study explores the connection between autoimmune responses in scleroderma patients and their risk of developing cancer. It suggests that certain antibody profiles could serve as biomarkers for predicting cancer risk in scleroderma patients.
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Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode