Exploring the Link Between Scleroderma and Cancer

This chapter investigates the intricate relationship between scleroderma and malignancies, particularly examining how specific antibody profiles could indicate a higher cancer risk in scleroderma patients and the hypothesis that cancer might trigger autoimmunity development. The study analyzes genetic alterations in cancer tissues related to scleroderma autoantigens, investigates the potential of using scleroderma autoantibodies as cancer risk biomarkers, and discusses the collaboration between Johns Hopkins and the University of Pittsburgh in exploring this connection.