The Joe Cohen Show Mastering Methylation: Understanding MTHFR, Homocysteine, and Folates with Dr. Denise Furness
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Nov 17, 2023 Dr. Denise Furness, distinguished molecular geneticist, discusses methylation's role in health, the impact of the MTHFR gene, optimal homocysteine levels, debunking concerns about over-methylation, and essential lab markers for optimizing health. They also explore the importance of folate intake, understanding gene expression, and the value of SelfDecode for genetic research.
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MTHFR's Role and Impact
- MTHFR gene converts folate into forms necessary for DNA synthesis and methylation.
- Variants like MTHFR 677TT reduce enzyme activity, potentially increasing homocysteine if folate or cofactors are low.
Limit High-Dose Methyl Folate
- Avoid high doses of methyl folate over 1 mg unless clinically indicated.
- High doses can cause feedback inhibition slowing the pathway and issues if supplements stop suddenly.
Avoid Single SNP Focus
- Don't focus on a single genetic SNP like MTHFR; look at multiple SNPs for a fuller picture.
- Adequate folate and cofactors like B2 can compensate for reduced MTHFR enzyme activity.