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Oncotarget

Editorial: Genomics Has More to Reveal

Jul 2, 2024
Laurène Fenwarth, a molecular researcher from the University of Lille, and Nicolas Duployez, an expert in acute myeloid leukemias from CHU Lille, share their insights on the evolving role of genomics in cancer treatment. They discuss how molecular and cytogenetic analyses reveal new mutations that aid in classifying acute myeloid leukemias and myelodysplastic syndromes. Despite significant advancements, 15% of AML cases remain genetically unclassifiable. Their discussion highlights the need for continued research and innovative bioinformatics to tackle these challenges.
02:33
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Episode guests

Nicolas Duployez
Laurène Fenwarth

Podcast summary created with Snipd AI

Quick takeaways

  • Molecular and cytogenetic analyses are pivotal in categorizing subtypes of AML and MDS, guiding targeted treatment decisions and risk stratification.
  • Despite advancements in genomic research, approximately 15% of AML cases remain unclassifiable, indicating persistent challenges in the field.

Deep dives

Genomic Advances in AML and MDS Treatment

Molecular and cytogenetic analyses are crucial for identifying mutations and structural variants that categorize distinct subtypes of acute myeloid leukemias (AML) and myelodysplastic syndrome (MDS). The editorial emphasizes that understanding these genetic factors is essential for stratifying risk and selecting effective treatments, such as allogeneic hematopoietic stem cell transplantation. Despite significant genomic research advances, around 15% of AML cases remain genetically unclassifiable, highlighting ongoing challenges in the field. The discussion includes specific mutations, such as FLT3-ITD and WT1, which are prevalent in certain AML cases and correlated with poor prognoses due to unidentified initiating events in a subset of patients.

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