The Paul Taylor Podcast
Wisdom Wednesdays: An Exciting New discovery in The Prevention of Alzheimer's Disease, and What it Means For You Irisin and AD
Oct 24, 2023
This podcast discusses the potential of Irisin, a myokine released from exercise, to prevent and treat Alzheimer's disease by reducing amyloid beta deposits in the brain. It also explores the role of exercise in brain health, focusing on high-intensity exercise and its ability to clear amyloid beta and release brain-derived neurotropic factor (BDNF) for optimal benefits.
09:44
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Quick takeaways
- Exercise, specifically higher intensity training, can help reduce amyloid beta deposits in Alzheimer's disease and trigger the release of BDNF for brain cell protection.
- Optimizing exercise intensity and type, such as high-intensity interval training and resistance training with full-body movements, can have significant benefits for the body and brain.
Deep dives
Exercise and Alzheimer's Disease
Exercise has shown promising results in reducing amyloid beta deposits in Alzheimer's disease. A myokine called a Risen, released from exercise, has been found to have a positive impact on clearing amyloid beta. A study at the Massachusetts General Hospital revealed that a Risen-based therapy led to a remarkable reduction in amyloid beta pathology in mouse models of Alzheimer's disease. This therapy activated the enzyme nepryllicin, which degrades amyloid beta. Exercise not only helps directly clear amyloid beta, but also triggers the release of BDNF, which protects brain cells.
