This podcast discusses the potential of Irisin, a myokine released from exercise, to prevent and treat Alzheimer's disease by reducing amyloid beta deposits in the brain. It also explores the role of exercise in brain health, focusing on high-intensity exercise and its ability to clear amyloid beta and release brain-derived neurotropic factor (BDNF) for optimal benefits.
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Quick takeaways
Exercise, specifically higher intensity training, can help reduce amyloid beta deposits in Alzheimer's disease and trigger the release of BDNF for brain cell protection.
Optimizing exercise intensity and type, such as high-intensity interval training and resistance training with full-body movements, can have significant benefits for the body and brain.
Deep dives
Exercise and Alzheimer's Disease
Exercise has shown promising results in reducing amyloid beta deposits in Alzheimer's disease. A myokine called a Risen, released from exercise, has been found to have a positive impact on clearing amyloid beta. A study at the Massachusetts General Hospital revealed that a Risen-based therapy led to a remarkable reduction in amyloid beta pathology in mouse models of Alzheimer's disease. This therapy activated the enzyme nepryllicin, which degrades amyloid beta. Exercise not only helps directly clear amyloid beta, but also triggers the release of BDNF, which protects brain cells.
Optimizing the Benefits of Exercise
To maximize the benefits of exercise, higher intensity training is recommended. Studies have shown that exercise intensity is a key regulator of muscle growth factors and myokine release. Cardiovascular exercises like high-intensity interval training and resistance training with full-body movements and higher weights are effective. These exercises recruit more muscles and optimize the release of a Risen and other beneficial myokines. High-intensity exercise has been shown to improve brain function, cognitive function, mood, physical health, and directly aid in clearing proteins. Optimizing exercise intensity and type can have significant benefits for both the body and the brain.
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The Role of Irisin in the Prevention and Treatment of Alzheimer's Disease