The Peter Attia Drive

Qualy #120 - What is the difference between ketone salts and esters?

Feb 28, 2020
Curious about ketone supplements? Dive into the fascinating differences between ketone salts and esters, focusing on beta-hydroxybutyrate (BHB). Discover the benefits and limitations of magnesium BHB and learn about dosing tips. The discussion also highlights the unique taste and potency of ketone compounds, revealing how their flavors have evolved over time. Get ready for a blend of science, innovation, and anecdotes that make the complex world of ketosis more relatable!
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INSIGHT

Ketone Salts vs. Esters

  • Ketone salts are ionic bonds between a ketone molecule and a cation like sodium, potassium, or an amino acid.
  • Ketone esters are covalent bonds, often involving 1,3 butanediol or glycerol.
ANECDOTE

Early Ketone Ester Experience

  • Peter Attia recounts consuming a large quantity of an early ketone ester, causing an unpleasant experience.
  • D'Agostino expresses surprise, revealing they had discussed proper dilution and consumption methods.
INSIGHT

Taste and Potency

  • Ketone salts generally have a palatable taste, while early ketone esters were notoriously unpleasant.
  • The palatability of ketone esters seems inversely related to their potency.
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