Siim Land Podcast #449 Matt Kaeberlein Unleashed: Rapamycin, Peptides, Protein, Supplements Q&A
Apr 17, 2025
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Rapamycin's Uncertain Human Impact
- Rapamycin's effects on human aging are still unknown without randomized clinical trials.
- Animal data supports lifespan extension, but human evidence is limited to anecdotal benefits and side effects like canker sores.
Caution with Antioxidants
- Avoid megadoses of antioxidants as excess can be harmful.
- Targeted antioxidants, especially mitochondrially directed, hold promise but need more research.
Prioritize Lifestyle Over Supplements
- Focus primarily on lifestyle improvements for longevity; supplements offer minor incremental benefits.
- Correct deficiencies with supplements like vitamin D; otherwise, prioritize diet, exercise, and sleep for healthspan.