JAMA Clinical Reviews Geroscience in Medicine
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Aug 7, 2025 In this discussion, Stephen B. Kritchevsky, a leading expert in geroscience from Wake Forest University, delves into the biology of aging. He explores the promising strategies for lifespan extension, including caloric restriction and the mTOR pathway. The conversation also highlights the crucial distinction between chronologic and biologic age, along with innovative anti-aging treatments like metformin. Kritchevsky emphasizes the importance of translating animal research to human health, revealing exciting prospects for improving our healthspan.
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Animal Models Show Aging Control
- Caloric restriction and manipulation of the mTOR pathway extend lifespan and healthspan in animal models.
- These findings suggest potential for analogous therapies targeting human aging processes.
Distinguishing Chronologic and Biologic Age
- Chronologic age counts years lived, while biologic age reflects health and disease risk status.
- Biologic age better predicts outcomes like mortality and dementia than chronological age alone.
Measuring Biologic Age
- Biologic age can be estimated using collections of physiologic and molecular measures, not just one metric.
- DNA methylation patterns, or methylomic clocks, are promising novel tools for measuring biologic age.