The Psychedelic Podcast James Fadiman, Ph.D. & Jordan Gruber, J.D. - The Power of Less: Microdosing for Mood, Energy, and Clarity
Aug 25, 2025
James Fadiman, Ph.D., the 'father of microdosing', and Jordan Gruber, J.D., a writer and former attorney, delve into the transformative potential of microdosing psychedelics. They explore how microdosing enhances mood, energy, and creativity while challenging traditional pharmaceutical approaches. The discussion covers personal experiences, healing benefits, and calls for increased research into microdosing's efficacy for mental health. Their work ignites curiosity about a holistic future where psychedelics could revolutionize our understanding of wellness.
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Microdosing As A Wellness Supplement
- Microdosing can be framed as a supplement that nourishes the nervous system rather than a pharmaceutical to fix symptoms.
- Jim and Jordan argue it promotes systemic wellbeing across physical, emotional, and performance domains.
Whole-Organism Effects vs. Symptom Drugs
- Pharmaceuticals target specific symptoms while microdosing appears to improve whole-organism functioning across domains.
- Jordan highlights emerging mechanisms like neuroplasticity and anti-inflammation as reasons for broad benefits.
Start With Subthreshold Doses
- Aim for subthreshold doses that produce no visuals or classic psychedelic effects.
- Use roughly one-tenth to one-twentieth of a full dose (e.g., 5–10 mcg LSD) as a starting rule of thumb.
