
The Day One Podcast 79 - The Iterative Mindset: Dr. Kyra Bobinet on Rethinking Motivation and Change
Nov 21, 2025
Dr. Kyra Bobinet, a physician and author of Unstoppable Brain, dives into the neuroscience of motivation and behavior change. She highlights the habenula, a brain structure that affects our mood and motivation, and explains how subtle failures can trigger this area, stalling our progress. Kyra contrasts iterative and growth mindsets, emphasizing how iteration enhances resilience. They discuss journaling as a tool for self-awareness and mental hygiene, offering prompts to reframe failure and reclaim personal narratives, while stressing the need for continuous adaptation in our practices.
AI Snips
Chapters
Books
Transcript
Episode notes
Habenula As TheBrain’sBrake
- The habenula is a tiny brain hub that controls motivation and mood by regulating dopamine and serotonin.
- When it detects disappointment or failure it acts like a brake and shuts down effort and desire to continue.
Subtle Failures Trigger Motivation Loss
- The habenula activates on subtle states like disappointment, demoralization, or disenchantment and stops behavior.
- This survival mechanism becomes a chief obstacle to long‑term change when triggered by everyday setbacks.
Walmart Associates Who Changed Their Lives
- Dr. Kyra studied Walmart associates who sustained health changes despite stress, and they all used iteration.
- Their success came from treating habits like practice, not perfect goals.

