Dr. Jockers Functional Nutrition

How Endotoxin Drives Inflammation with Christian Yordanov

Jul 22, 2025
Christian Yordanov, a longevity author and functional health practitioner, shares illuminating insights on the hidden driver of chronic illness: endotoxins. He explains how these toxic fragments from gut bacteria can create widespread inflammation, leading to fatigue and brain fog. The conversation challenges common health beliefs about fiber and gut health, offering personalized dietary strategies. Yordanov also highlights the importance of detoxification practices and lifestyle changes to enhance gut health and overall well-being.
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INSIGHT

Endotoxins Trigger Chronic Inflammation

  • Endotoxins from gut gram-negative bacteria leak into blood causing chronic inflammation.
  • This inflammation damages gut lining, increasing intestinal permeability and systemic immune response.
ADVICE

Fiber Can Fuel Endotoxin Production

  • Avoid overfeeding gut bacteria with excessive fiber if gut bacteria are overgrown.
  • Tailor fiber intake to individual gut health and balance endotoxin production.
INSIGHT

Endotoxin Damages Gut Mitochondria

  • Endotoxins damage mitochondria, shifting energy production to glycolysis.
  • This creates excess gut oxygen, favoring pathogenic aerobic bacteria growth.
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