Results of Hypertonic Saline or Mannitol Clinical Trial for Treatment of Children with Severe TBI

In this World Shared Practice Forum podcast, Dr. Patrick Kochanek discusses the results of the ADAPT trial, published in JAMA Open Network, which compares intracranial pressure measurements in children with severe traumatic brain injury following administration of hypertonic saline versus mannitol. He outlines the key findings of the ADAPT trial, describes some of the challenges and limitations that accompanied the study, and provides insight into the potential impact on the management of pediatric traumatic brain injury. Publication date: April 25, 2022. Citation: Kochanek P, Daniel D, Burns JP. Results of a Clinical Trial of Hypertonic Saline or Mannitol in the Treatment of Children With Severe Traumatic Brain Injury. 04/2022. Online Podcast. OPENPediatrics. https://youtu.be/ZdnaccURMVQ. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open-access and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu