Oncotarget
Can Mechanisms of Hair Loss Shed Light on Cancer and Aging?
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Quick takeaways
- Apoptotic cells play a crucial role in driving cell death during hair follicle regression, with a propagated mechanism induced by apoptotic cells inducing apoptosis in neighboring cells.
- Stem cell niches and their role in hair follicle regression are important to understand the dynamics of hair follicle regression, with mesenchymal dermal papilla cells initiating regression through the release of a pro-apoptotic signal.
Deep dives
The Role of Apoptotic Cells in Hair Follicle Regression
Researchers have shed light on the role of apoptotic cells in hair follicle regression and cell death. Through their study, they found that apoptotic cells play a crucial role in driving cell death during hair follicle regression. The elimination of epithelial cells involves super basal cell differentiation and basal cell apoptosis, influenced by the synergistic action of TGF beta and mesenchymal epithelial interactions. The researchers proposed a quantitative analysis of the length of hair follicles during their regression cycle, suggesting a propagation mechanism driven by apoptotic cells inducing apoptosis in their neighboring cells. Additionally, apoptosis slows down as it approaches the stem cells at the end of the follicle, indicating the presence of a pro-survival signal released by these stem cells.
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