Hair follicles are dynamic structures that undergo cyclic phases of growth, regression and quiescence. The growth phase, known as anagen, lasts for several years, followed by a short regression phase called catagen. During catagen, most cells within the follicle undergo programmed cell death, but a small population of stem cells remains viable to replenish the follicle during the subsequent growth phase. Understanding the mechanisms involved in hair follicle regression is not only important for elucidating normal tissue homeostasis but also for studying pathological conditions such as cancer and aging.
In a recent study, researchers Bradley D. Keister, Kailin R. Mesa and Krastan B. Blagoev from the National Science Foundation, The Jane Coffin Childs Memorial Fund for Medical Research, Yale School of Medicine, Johns Hopkins University, Bulgarian Academy of Sciences, and Sorbonne Université shed light on the role of apoptotic cells in hair follicle regression and cell death. Their research paper was published in Oncotarget on October 19, 2023, entitled, “Apoptotic cells may drive cell death in hair follicles during their regression cycle.”
“Here, we use a quantitative analysis of the length of hair follicles during their regression cycle.”
Full blog - https://www.oncotarget.org/2023/11/29/can-mechanisms-of-hair-loss-shed-light-on-cancer-and-aging/
Paper DOI - https://doi.org/10.18632/oncotarget.28529
Correspondence to - Krastan B. Blagoev - kblagoev@nsf.gov
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Keywords - cancer, hair follicle, stem cells, regression cycle, mathematical model, analysis
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