Health Longevity Secrets

Does Mouthwash Cause Hypertension? with Dr Nathan Bryan

Sep 23, 2025
Dr. Nathan Bryan, a researcher and physiologist specializing in nitric oxide, delves into the critical roles this molecule plays in circulation and vascular health. He reveals startling effects of mouthwash on nitric oxide production, linking it to increased blood pressure. The conversation also highlights the dangers of proton pump inhibitors, which can elevate heart disease risks. Bryan explains how optimizing nitric oxide can enhance erectile dysfunction medications and shares practical tips for boosting nitric oxide naturally through lifestyle changes.
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INSIGHT

Nitric Oxide Is Foundational To Health

  • Nitric oxide is a tiny gaseous signaling molecule that regulates blood flow, neurotransmission, immunity, and mitochondrial function.
  • Nathan S. Bryan argues nitric oxide production is foundational to health and longevity and impacts many age-related diseases.
INSIGHT

Two Distinct Nitric Oxide Pathways

  • There are two primary nitric oxide pathways: endothelial enzymatic production and oral bacteria conversion of dietary nitrate.
  • Loss of either pathway can cause endothelial dysfunction and widespread vascular problems.
ADVICE

Stop Daily Antiseptic Mouthwash Use

  • Avoid daily antiseptic mouthwash and fluoride-containing toothpaste because they destroy beneficial oral bacteria that create nitrite and nitric oxide.
  • Stopping these products lets the oral microbiome recover and can restore nitric oxide production and blood pressure control.
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