#12: Panic Attacks, DHT, Prostate Cancer, Receptors, Pollution, and Estrogen with Georgi Dinkov
Oct 5, 2019
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Georgi Dinkov discusses the potential of DHT in treating prostate cancer and how estrogen promotes it. The impact of poverty on cognitive function and aging. The connection between energy deficiency, stress, and anxiety. The potential protective effects of aspirin against air pollution. Super chat questions round off the episode.
Aspirin shows promise in protecting lungs from air pollution and mitigating inflammation.
Chronic stress alters gene expression related to anxiety disorders and reduces lung function.
Poverty negatively impacts cognitive abilities and accelerates cellular aging.
Low-dose aspirin may restore lung function and counter the inflammatory effects of air pollution.
Heart palpitations can be alleviated by increasing calcium and sodium intake, consuming orange juice, and potentially using progesterone or thyroid support.
Deep dives
Air Pollution and Lung Function
Air pollution, particularly particulate matter, can have detrimental effects on lung function. However, a study found that aspirin was able to block the inflammatory response caused by pollution and even restore lung function to near-normal levels. The study also found that exposure to air pollution had similar effects on lung function as smoking. Aspirin's ability to mitigate inflammation and protect against pollution-related damage makes it a potential therapeutic option for individuals living in highly polluted areas.
Stress, Serotonin, and Anxiety Disorders
Chronic stress is known to have adverse effects on mental health, including anxiety disorders. A study demonstrated that chronic stress leads to changes in the genes responsible for serotonin metabolism, reduced lung function. The study also found that individuals with anxiety disorders displayed the same gene expression profile as mice susceptible to stress-induced anxiety. The findings suggest that serotonin plays a role in anxiety disorders and that reducing stress and serotonin levels may be beneficial in managing anxiety.
The Impact of Poverty on Intelligence and Aging
Poverty can have detrimental effects on intelligence, cognitive function, and aging. A study found that individuals who were previously highly educated and part of the upper middle class but fell into poverty experienced a decline in cognitive abilities similar to those living in long-term poverty. Poverty was also found to significantly accelerate aging at a cellular level, resulting in individuals appearing 10 to 15 years older than their chronological age. These findings challenge the notion that intelligence and poverty are solely predetermined traits and highlight the importance of addressing socioeconomic factors in promoting cognitive health and healthy aging.
Aspirin's Protective Effects Against Air Pollution-Induced Lung Damage
Air pollution has become a significant problem in many urban areas, leading to various health issues, including lung damage. However, a study found that aspirin, even in low doses of 80 to 100 mg, could restore lung function and mitigate the inflammatory response caused by pollution. Aspirin's anti-inflammatory properties and its ability to counter the harmful effects of air pollution make it a potential therapeutic option for individuals exposed to high levels of pollution.
Possible solutions to heart palpitations
Possible solutions for heart palpitations include hormonal imbalances such as elevated cortisol and estrogen, as well as electrolyte deficiencies, particularly in calcium. Increasing calcium intake, sodium intake, or consuming foods rich in calcium and sodium like milk or pecorino romano cheese may help alleviate heart palpitations. Orange juice, which contains flavonoids like hisperidin, apigenin, and naringin, may also provide relief. Additionally, the hormone progesterone and thyroid hormones have been found to stabilize heart rhythms and reduce palpitations. Improving dietary intake and potentially using progesterone or thyroid support may help address heart palpitations.
Factors influencing cold hands and feet
Having cold hands and feet can indicate elevated adrenaline levels and reduced thyroid function. While brief moments of cold hands and feet during extremely stressful situations may not necessarily indicate suppressed thyroid function, if it is a recurring issue, it can be a reliable sign of an underactive thyroid and elevated adrenaline. Consuming salty foods and observing improved temperature in the extremities can be indicative of elevated adrenaline. Acid reflux after esophagitis diagnosis can be caused by cortisol weakening the sphincter, and elevated cortisol-to-DHEA ratio can contribute to the loosening of the sphincter. Inflammatory conditions, such as GERD, can be relieved by increasing glycine intake to protect the esophageal and stomach lining.
Considerations for calcium intake with thyroid medication
Mainstream recommendations caution against taking calcium in close proximity to thyroid synthetic or natural desiccated thyroid (NDT) medications. While some warnings suggest that calcium may bind with thyroid hormones, their overall impact on medication effectiveness is questionable. Individual responses to calcium intake alongside thyroid medication can vary. It is important to note that concerns about timing and calcium intake are less significant compared to overall medication effectiveness and metabolic support. It is advisable to prioritize consistent and adequate thyroid medication intake alongside a nutrient-rich diet to support overall thyroid health.
Toxicity of High Doses of Aspirin
Studies have shown that taking over one gram of aspirin in a single dose can lead to ringing in the ears, known as auto toxicity. However, the ringing tends to disappear within 24 hours after stopping the high dosage. It is recommended to take one gram or three grams of aspirin daily in divided doses to minimize the risk of auto toxicity. An interesting study found that adding a small amount of vitamin K to the dose of aspirin can help prevent the ringing in the ears. Glycine has also been found to counteract some of the toxic effects of aspirin. Taking a gelatin supplement or a combination of aspirin and glycine has shown promising results in mitigating these effects.
Appropriate Dose of Siprheptadine and Side Effects
For blocking the serotonin receptor, a dosage of 2 milligrams or higher is usually sufficient. However, lower dosages of 1 to 2 milligrams have been effective for improving digestion and symptoms of chronic fatigue syndrome. Higher doses of 24 to 32 milligrams have been used for severe cases of Cushing syndrome. It is advisable to start with lower doses to minimize sedation effects, gradually increasing the dosage if necessary. Some individuals may experience elevated liver enzymes with higher doses of siprheptadine, indicating caution when considering these higher doses.
