The Adversity Advantage with Doug Bopst NAD: The Molecule That Controls How Fast You Age | Dr. Andrew Salzman
Nov 29, 2025
Dr. Andrew Salzman is a Harvard-educated physician and biomedical entrepreneur with over 30 years of research in NAD biology. He dives into the fascinating role of NAD in aging and energy production. The conversation reveals how inflammation drives aging and why diet impacts NAD efficiency. Salzman critiques NAD IV drips as ineffective while promoting precursors like NR and NMN. He also discusses innovative strategies combining NMN with CD38 inhibitors for optimal benefits, linking NAD to cognition, stamina, and even hair health.
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NAD As The Central Aging Molecule
- NAD is the central molecule coordinating energy, DNA repair, and longevity-related processes across the body.
- Falling NAD levels with age drive many aging symptoms and make NAD a key intervention target.
Change Diet And Exercise To Preserve NAD
- Improve NAD by eating a balanced, lower-carb or keto-style diet and exercising regularly.
- Avoid high-sugar diets because they consume more NAD and reduce efficiency of ATP production.
Inflammation Drives NAD Loss Via CD38
- CD38 is the primary enzyme that degrades NAD and its levels rise with age.
- Chronic low-level inflammation drives CD38 up, causing progressive NAD depletion.