The Dr. Gabrielle Lyon Show Hormone Replacement Therapy Decoded: Why the FDA Removed the Blackbox Warning on HRT
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Dec 23, 2025 
In this engaging discussion, Gabrielle Lyon, a leading expert in muscle-centric medicine, unpacks the recent FDA change to hormone replacement therapy (HRT) and its implications for menopause care. She addresses the importance of accurate hormone testing and the safety of testosterone for women. The conversation reveals the cognitive and physical benefits of balanced hormones, highlights testosterone's positive effects on energy and libido, and clarifies who should avoid HRT. Nick prompts deeper exploration into these critical health topics throughout.
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Black Box Removal Changes HRT Landscape
- The FDA removed the black box warning on menopausal HRT after re-evaluating long-term data and risks from the Women's Health Initiative.
- This change reopens HRT as a safer option for many women and shifts the landscape of women's health care.
Ask For Mass-Spec Testing
- Request liquid chromatography tandem mass spectrometry (LC-MS/MS) when testing testosterone to get accurate results.
- Compare lab units carefully so you interpret testosterone values correctly across assays and labs.
Use Correct Testosterone Ranges
- Use age- and menopausal-status reference ranges and compare like-for-like units when evaluating women's total and free testosterone.
- Focus on free testosterone as the bioavailable fraction when assessing symptoms and dosing.