Biohacking Beauty: The Anti-Aging Skincare Podcast Nathalie Niddam: Peptides, Bioregulators, and the Truth About Skin Longevity
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Nov 12, 2025 Nathalie Niddam is a longevity practitioner and peptide expert who guides clients on skin longevity strategies. She discusses the vital role of inflammation in peptide effectiveness and the misconceptions around anti-aging treatments. Nathalie clarifies the differences between signaling peptides and bioregulators while sharing potential gut health impacts. She emphasizes starting with bioregulators for repair and cautions against self-prescribing. Additionally, she offers practical hacks for skin health, like optimizing sleep and hydration.
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Peptides Vs Building Materials
- Peptides are small proteins that act mainly as signaling molecules, not raw materials like amino acid supplements.
- A subset called bioregulators (2–4 amino acids) can enter cells and act as epigenetic switches to turn genes on or off.
Instructions Need Materials And No Fire
- Peptides provide instructions (signals) while nutrients provide the building blocks for repair.
- Without adequate materials or with active inflammation, signaling peptides cannot produce intended results.
Unresolved Inflammation Is The Hidden Blocker
- Chronic unresolved inflammation is the 'fire' that prevents repair and ages tissue.
- Gut inflammation and leaky gut are foundational drivers of systemic inflammation and poor skin outcomes.