ImmunoTea: Your Immunology Podcast
ImmunoTea Episode 12 - Autoinflammatory Syndromes
Dec 18, 2023
In this episode, the hosts interview Prof Helen Lachmann about autoinflammatory syndromes, discussing their presentation, diagnosis, and treatment. They also cover diverse symptoms and the use of IL-1 blockade as a treatment option. The chapter on AA amyloidosis explores its causes, management, and prevention. Acquired autoinflammatory diseases in adults and the relationship between somatic mosaicism and critical gene changes are also discussed. The hosts express gratitude and bid farewell to the listeners for the year.
44:15
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Quick takeaways
- Autoinflammatory diseases are characterized by the overproduction of inflammatory cytokines and represent disorders of innate immune system overactivation.
- AA amyloidosis, a major complication of auto-inflammatory diseases, can be entirely prevented by effectively treating the underlying chronic inflammatory disease.
Deep dives
Auto-inflammatory diseases are disorders of innate immunity
Auto-inflammatory diseases are defined as disorders of innate immunity that involve upregulation of the innate immune response, driven by neutrophil and monocyte activation of macrophages. These diseases are distinct from classic autoimmune diseases and are characterized by the overproduction of inflammatory cytokines. Auto-inflammatory diseases were initially recognized in the 20th century, and while most are genetic, there are also acquired forms of these diseases. The understanding of auto-inflammatory diseases has evolved, recognizing a spectrum between innate and acquired immunity, with auto-inflammatory diseases representing disorders of innate immune system overactivation.
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